Avoparcin
250px α-Avoparcin (R=H)
β-Avoparcin (R=Cl) |
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Identifiers | |
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37332-99-3 (α/β mix) ![]() 73957-86-5 (α) ![]() 73957-87-6 (β) ![]() |
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ChemSpider | 16736403 (α) 16736404 (β) |
Jmol 3D model | (α): Interactive image (β): Interactive image |
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Properties | |
C89H102ClN9O36 (α) C89H101Cl2N9O36 (β) |
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Molar mass | 1909.254 (α) 1943.699 (β) |
Vapor pressure | {{{value}}} |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references | |
Avoparcin is a glycopeptide antibiotic effective against Gram-positive bacteria. It has been used in agriculture as an additive to livestock feed to promote growth in chickens, pigs, and cattle.[1] It is also used as an aid in the prevention of necrotic enteritis in poultry.[1]
Avoparcin is a mixture of two closely related chemical compounds, known as α-avoparcin and β-avoparcin, which differ by the presence of an additional chlorine atom in β-avoparcin. Avoparcin also shares a chemical similarity with vancomycin. Because of this similarity, concern exists that widespread use of avoparcin in animals may lead to an increased prevalence of vancomycin-resistant strains of bacteria.[2][3][4][5]
Avoparcin was once widely used in Australia and the European Union, but it is currently not permitted in either.[1][6] It was never approved for use in the United States.[7]
References
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- ↑ Commission Directive 97/6/EC of 30 January 1997 amending Council Directive 70/524/EEC concerning additives in feedingstuffs, Official Journal L 035 , 05/02/1997 P. 0011-0013
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
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- Glycopeptide antibiotics