Bithorax complex
The Bithorax complex (BX-C) is a group of homeotic genes in Drosophila melanogaster which are believed to control the differentiation of the abdominal and posterior thoracic segments, located on chromosome III.[1] When these genes are mutated, the third thoracic segment becomes a repeat of the second thoracic segment, creating what is essentially a second thorax. This can result in a second pair of wings, a second stomach, and duplicated thoracic features in varying degrees.[2]
The complex includes Ultrabithorax (Ubx), Abdominal A (abd-A) and Abdominal B (Abd-B).[3]
Calvin Bridges discovered Bithorax (mutation/gene) in the fly in 1915; after that, Edward B. Lewis named and worked on the Bithorax complex[4] and proposed a model in a classic Nature paper in 1978 and was given a Nobel Prize.[5]
References
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- ↑ Developmental biology. Scott F. Gilbert
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