Brushfield spots
Brushfield spots are small, white or grayish/brown spots on the periphery of the iris in the human eye due to aggregation of connective tissue, a normal iris element. The spots are named after the physician Thomas Brushfield, who first described them in his 1924 M.D. thesis.[1]
These spots are normal in children (Kunkmann-Wolffian bodies), but are also a feature of the chromosomal disorder Down syndrome. They occur in 35–78% of newborn infants with Down syndrome.[2] They are much more likely to occur in children with Down syndrome of the Caucasian race than children of Asian heritage with Down's Syndrome.[3]
They are focal areas of stromal hyperplasia, surrounded by relative hypoplasia, and are more common in patients with lightly pigmented irises.[citation needed]
References
- ↑ Wallis, Hugh R.E. "The Significance of Brushfield's Spots in the Diagnosis of Mongolism in Infancy", Archives of Disease in Childhood, 1951 December; 26 (130): 495-500. Retrieved on 21 March 2009.
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