DDX20

Probable ATP-dependent RNA helicase DDX20, also known as gem-associated protein 3 or GEMIN3 is an enzyme that in humans is encoded by the DDX20 gene.

Function

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neuron protein (SMN) complex. This DEAD box protein is one of the gem-associated proteins (GEMIN3) that interacts directly with SMN. SMN is the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs.

Interactions

DDX20 has been shown to interact with:

• EIF2C2,
• GEMIN4,
• GEMIN5,
• LSM2,
• SMN1,
• SNRPB,
• SNRPD3 and
• SNRPG,
• SNRPD1,
• SNRPD2,
• SNRPE,
• SNRPF, and
• SIP1.