DGKQ

Diacylglycerol kinase, theta 110kDa
Identifiers
Symbols	DGKQ ; DAGK; DAGK4; DAGK7
External IDs	OMIM: 601207 MGI: 102918 HomoloGene: 20352 GeneCards: DGKQ Gene
EC number	2.7.1.107
Gene ontology Molecular function • diacylglycerol kinase activity • protein binding • ATP binding • kinase binding • activating transcription factor binding • phospholipase binding • metal ion binding Cellular component • nucleus • cytoplasm • cytosol • cytoskeleton • plasma membrane • nuclear speck Biological process • regulation of transcription from RNA polymerase II promoter • G-protein coupled receptor signaling pathway • protein kinase C-activating G-protein coupled receptor signaling pathway • blood coagulation • phosphorylation • cAMP-mediated signaling • platelet activation • response to ATP • thrombin receptor signaling pathway • protein kinase C signaling Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE DGKQ 207562 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1609	110524
Ensembl	ENSG00000145214	ENSMUSG00000004815
UniProt	P52824	Q6P5E8
RefSeq (mRNA)	NM_001347	NM_199011
RefSeq (protein)	NP_001338	NP_950176
Location (UCSC)	Chr 4: 0.96 – 0.99 Mb	Chr 5: 108.65 – 108.67 Mb
PubMed search	[1]	[2]

Diacylglycerol kinase theta is an enzyme that in humans is encoded by the DGKQ gene.

The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.

Interactions

DGKQ has been shown to interact with RHOA.