PARK7
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Protein deglycase DJ-1, also known as Parkinson disease protein 7, is a protein which in humans is encoded by the PARK7 gene.[1]
Contents
Gene
The gene PARK7, also known as DJ-1, encodes a protein of the peptidase C56 family. The human gene PARK7 has 8 Exons and locates at chromosome band 1p36.23.[1]
Protein
The human protein deglycase DJ-1 is 20 kDa in size and composed of 189 amino acids with seven β-strands and nine α-helices in total and is present as a dimer.[2][3][4] It belongs to the peptidase C56 family of proteins.
The protein structures of human protein DJ-1, Escherichia coli chaperone Hsp31 and an Archaea protease are evolutionarily conserved.[5]
Function
Under an oxidative condition, protein deglycase DJ-1 inhibits the aggregation of α-synuclein via its chaperone activity,[6][7] thus functions as a redox-sensitive chaperone and as a sensor for oxidative stress. Accordingly, DJ-1 apparently protects neurons against oxidative stress and cell death.[1] In parallel, Protein DJ-1 acts as a positive regulator of androgen receptor-dependent transcription.
Pyrroloquinoline_quinone (PQQ) has been shown to reduce the self-oxidation of the DJ-1 protein, an early step in the onset of some forms of Parkinson's disease.[8]
Clinical significance
Defects in this gene are the cause of autosomal recessive early-onset Parkinson's disease 7.[1][9]
Interactions
PARK7 has been shown to interact with:
See also
References
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Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.