EIF4EBP1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Eukaryotic translation initiation factor 4E-binding protein 1 is a protein that in humans is encoded by the EIF4EBP1 gene.[1]
Function
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of cap-dependent mRNA translation.[2]
Interactions
EIF4EBP1 has been shown to interact with:
- EIF4E,[3][4][5][6][7][8][9][10][11][12][13][14][15]
- KIAA1303,[7][16][17][18][19][20][21][22] and
- Mammalian target of rapamycin (mTOR).[16][17][18][19][23][24][25][26]
References
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Further reading
- Lua error in package.lua at line 80: module 'strict' not found.
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