FARP2

FERM, RhoGEF and pleckstrin domain protein 2
Identifiers
Symbols	FARP2 ; FIR; FRG; PLEKHC3
External IDs	MGI: 2385126 HomoloGene: 8877 GeneCards: FARP2 Gene
Gene ontology Molecular function • Rho guanyl-nucleotide exchange factor activity • cytoskeletal protein binding • Rac guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • cytosol • cytoskeleton • extrinsic component of membrane Biological process • cell adhesion • axon guidance • neuron remodeling • Rac protein signal transduction • osteoclast differentiation • actin cytoskeleton reorganization • regulation of integrin activation • regulation of Rho protein signal transduction • positive regulation of GTPase activity • semaphorin-plexin signaling pathway • podosome assembly Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE FARP2 204511 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9855	227377
Ensembl	ENSG00000006607	ENSMUSG00000034066
UniProt	O94887	Q91VS8
RefSeq (mRNA)	NM_001282983	NM_145519
RefSeq (protein)	NP_001269912	NP_663494
Location (UCSC)	Chr 2: 241.36 – 241.49 Mb	Chr 1: 93.51 – 93.62 Mb
PubMed search	[1]	[2]

FERM, RhoGEF and pleckstrin domain-containing protein 2 is a protein that in humans is encoded by the FARP2 gene.

Model organisms

Farp2 knockout mouse phenotype

Characteristic	Phenotype
Homozygote viability	Normal
Fertility	Normal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology	Normal
Micronucleus test	Normal
Heart weight	Normal
Tail epidermis wholemount	Normal
Skin Histopathology	Abnormal
Brain histopathology	Abnormal
Salmonella infection	Normal
Citrobacter infection	Normal
All tests and analysis from

Model organisms have been used in the study of FARP2 function. A conditional knockout mouse line, called Farp2^{tm1a(KOMP)Wtsi} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on mutant mice and two significant abnormalities were observed. Homozygous mutant animals had a thickened cerebral cortex and displayed abnormal hair shedding.

Interactions

FARP2 has been shown to interact with PDZK1.