File:Sequential sections of a colon crypt showing normal high expression of PMS2 (A), ERCC1 (B) and ERCC4 (C).jpg.tif

Summary

Sequential sections of the same <a href="//commons.wikimedia.org/w/index.php?title=Large_intestine&action=edit&redlink=1" class="new" title="Large intestine (page does not exist)">colon crypt</a> with <a href="//commons.wikimedia.org/wiki/Immunohistochemistry" title="Immunohistochemistry">immunohistochemical</a> staining (brown) showing normal high expression of DNA repair proteins <a href="//commons.wikimedia.org/w/index.php?title=PMS2&action=edit&redlink=1" class="new" title="PMS2 (page does not exist)">PMS2</a> (A), <a href="//commons.wikimedia.org/w/index.php?title=ERCC1&action=edit&redlink=1" class="new" title="ERCC1 (page does not exist)">ERCC1</a> (B) and <a href="//commons.wikimedia.org/w/index.php?title=ERCC4&action=edit&redlink=1" class="new" title="ERCC4 (page does not exist)">ERCC4</a> (XPF) (C). This crypt is from the biopsy of a 58 year old male patient who never had colonic <a href="//commons.wikimedia.org/w/index.php?title=Neoplasm&action=edit&redlink=1" class="new" title="Neoplasm (page does not exist)">neoplasia</a> and the crypt has high expression of these DNA repair proteins in absorptive cell nuclei throughout most of the crypt. Note that PMS2 and ERCC4 (XPF) expression (in panels A and C) are each reduced or absent in the <a href="//commons.wikimedia.org/w/index.php?title=Cell_nucleus&action=edit&redlink=1" class="new" title="Cell nucleus (page does not exist)">nuclei</a> of cells at the top of the crypt and within the surface of the colonic <a href="//commons.wikimedia.org/w/index.php?title=Lumen_(anatomy)&action=edit&redlink=1" class="new" title="Lumen (anatomy) (page does not exist)">lumen</a> between crypts. Original image, also in a publication.^{<a href="#cite_note-Facista-1">[1]</a>}

Licensing

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