GADD45A
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Growth arrest and DNA-damage-inducible protein GADD45 alpha is a protein that in humans is encoded by the GADD45A gene.[1][2][3]
Function
This gene is a member of a group of genes, the GADD45 genes, whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents (mutagens). The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase.[3]
Applications
The fact that expression of this gene is an indicator of DNA damage has been exploited to construct an in vitro test for mutagenicity, the GADD45a-GFP GreenScreen HC assay.[4] This assay consists of a cell line which has been engineered so that expression of GADD45A will lead to expression of green fluorescent protein, which can easily be detected. To test a substance for mutagenicity, it is applied to these cells and fluorescence is measured.
Interactions
GADD45A has been shown to interact with:
- AURKA,[5][5]
- Cdk1,[6][7][8][9]
- CCNB1,[6][9]
- GADD45GIP1[10]
- MAP3K4,[11]
- P21,[8][12] and
- PCNA.[8][13][14][15][16]
See also
References
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Further reading
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