GPS2 (gene)
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). G protein pathway suppressor 2 is a protein that in humans is encoded by the GPS2 gene.[1][2]
Function
This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.[2]
Interactions
GPS2 (gene) has been shown to interact with:
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References
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Further reading
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