Gadoteric acid

Gadoteric acid

Systematic (IUPAC) name
gadolinium(+3) cation; 2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetate
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	72573-82-1 Y
ATC code	V08CA02 (WHO)
PubChem	CID: 3085828
UNII	QVF9Y6955W N
KEGG	D08007 Y
Chemical data
Formula	C16H25GdN4O8
Molecular mass	558.64 g/mol
NY (what is this?)  (verify)

Gadoteric acid (trade names Artirem, Dotarem or Dotagita) is a macrocycle-structured gadolinium-based MRI contrast agent. It consists of the organic acid DOTA as a chelating agent, and gadolinium (Gd³⁺), and is used in form of the meglumine salt. The drug is approved and used in a number of countries worldwide. It is used to assist imaging of blood vessels and of inflamed or diseased tissue where the blood vessels become 'leaky'. It is often used when viewing intracranial lesions with abnormal vascularity or abnormalities in the blood–brain barrier. Its paramagnetic property reduces the T1 relaxation time (and to some extent the T2 and T2* relaxation times) in MRI, which is the source of its clinical utility.