Gregory Goodwin Pincus

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Gregory Goodwin Pincus
Gregory Pincus.jpg
Born (1903-04-09)April 9, 1903
Woodbine, New Jersey, U.S.
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Boston, Massachusetts, U.S.
Residence Northborough, Massachusetts
Citizenship United States
Fields Biology
Institutions Harvard University
Worcester Foundation for Experimental Biology
Alma mater Cornell University
Harvard University
Known for Combined oral contraceptive pill
Spouse Elizabeth Notkin (died in 1988)

Dr. Gregory Goodwin Pincus (April 9, 1903 – August 22, 1967) was an American biologist and researcher who co-invented the combined oral contraceptive pill.[1]

Birth and education

Gregory Goodwin Pincus was born in Woodbine, New Jersey, into a Jewish family, the son of Polish-born immigrants Elizabeth (née Lipman) and Joseph Pincus, an agriculture teacher.[2] He credited two uncles, both agricultural scientists, for his interest in research. He went to Cornell University and received a bachelor's degree in agriculture in 1924. He attended Harvard University where he was an instructor in zoology while also working toward his master's and doctorate degrees. From 1927 to 1930 he moved from Harvard to Cambridge University in England to the Kaiser Wilhelm Institute for Biology with Richard Goldschmidt in Berlin where he performed research. He became an instructor in general physiology at Harvard University in 1930 and was promoted in 1931 to an assistant professor.


Dr. Gregory Pincus (left) with Sir John Hammond and Dr. Min Chueh Chang

Dr. Pincus began studying hormonal biology and steroidal hormones early in his career. He was interested in the way that hormones affected mammals' reproductive systems. His first breakthrough came early, when he was able to produce in vitro fertilization in rabbits in 1934. In 1936, he published his discoveries after his experiments. His experiments involving parthenogenesis produced a rabbit that appeared on the cover of Look magazine in 1937, which may have been a reason for Harvard's having denied Pincus tenure.[clarification needed] To create the in vitro rabbit baby, Pincus removed the ovum from the mother rabbit and placed it in a solution mixture of saline and estrone. Afterwards, he placed the "fertilized" ovum back into the rabbit. Pincus' experiment became known as "Pincogenesis" because other scientists were unable to attain the same results when conducting the experiment. After his experiment, Pincus began to be acknowledged, but for the wrong reasons.[clarification needed] After he was misquoted in an interview, it was believed that his experiment was the beginning of the use of in vitro for humans.[3]

In 1944, Dr. Pincus co-founded the Worcester Foundation for Experimental Biology in Shrewsbury, Massachusetts. He wanted to continue his research of the relationship between hormones and diseases such as, but not limited to, cancer, heart disease, and schizophrenia. By the end of the 1960s, more than 300 international researchers came to participate in the Worcester Foundation of Experimental Biology.[4]

Pincus never lost interest in mammals' reproduction systems. He began to research infertility.[4] In 1951, Margaret Sanger met Pincus at a dinner hosted by Abraham Stone, director of the Margaret Sanger Research Bureau and medical director and vice president of Planned Parenthood Federation of America (PPFA), and procured a small grant from PPFA for Pincus to begin hormonal contraceptive research. Pincus, along with Min Chueh Chang, confirmed earlier research that progesterone would act as an inhibitor to ovulation.

In 1952, Sanger told her friend Katharine McCormick about Pincus and Chang's research. Frustrated by PPFA's meager interest and support, McCormick and Sanger met with Pincus in 1953 to dramatically expand the scope of the research with 50-fold increase in funding from McCormick. Pincus was fascinated by Sanger because she revealed what life was like for poor women who had to endure many pregnancies. She indirectly influenced him to create a successful contraceptive to prevent unwanted pregnancies.[4]

In order to prove the safety of "the pill," human trials had to be conducted. These were initiated on infertility patients of Dr. John Rock in Brookline, Massachusetts using progesterone in 1953 and then three different progestins in 1954. Puerto Rico was selected as a trial site in 1955, in part because there was an existing network of 67 birth control clinics serving low-income women on the island. Trials began there in 1956 and were supervised by Dr. Edris Rice-Wray.

Some of the women experienced side effects from "the pill" (Enovid) and Dr. Edris Rice-Wray wrote Pincus and reported that Enovid "gives one hundred percent protection against pregnancy [but causes] too many side reactions to be acceptable". Pincus and Rock disagreed based on their experience with patients in Massachusetts and conducted research showing that placebos caused similar side effects. The trials went on and were expanded to Haiti, Mexico and Los Angeles despite high attrition rates, due to the large number of women eager to try this form of contraception.

In May 1960, the FDA extended Enovid's approved indications to include contraception.

Personal life

Pincus married Notkin (1900-1988) in 1924 and they had three children together.[4]


He has received a number of awards. Some of these awards include the Oliver Bird Prize in 1960, the Julius A. Koch Award in 1962, and the American Medical Association's Scientific Achievement Award in 1967.[4] Pincus was acknowledged for his creation of the Laurentian Hormone Conference, which was a conference of endocrinologists. He was the chairman of the conference. The purpose of the conference was to discuss the hormones of the endocrine system. The conference was attended by endocrinologists from all over.


He died in 1967 of myeloid metaplasia, a rare blood disease, in Boston, Massachusetts. He was 64 years old and lived in Northborough, Massachusetts.[1] His funeral was held August 25, 1967 at Temple Emanuel in Worcester, Massachusetts.[5]

Lasting Impact

Pincus' birth control pill changed family life because it allowed couples to do as they please without having to worry about having more children. Women increased control of their family life and sexual behavior, which changed the way that women and relationships were viewed, and paved the way for the Sexual Revolution.[4]

See also


  1. 1.0 1.1 Lua error in package.lua at line 80: module 'strict' not found.
  2. Encyclopedia of World Biography on Gregory Goodwin Pincus
  3. Charles W. Carey, Jr.. "Pincus, Gregory Goodwin";
  4. 4.0 4.1 4.2 4.3 4.4 4.5 Carey
  5. "Dr. Pincus, Developer of Birth Control Pill, Dead; Funeral Services to Be Held Friday." Jewish Telegraphic Agency 24 Aug 1967.

Further reading

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  • Weintraub, B. Pincus, Djerassi and Oral Contraceptives. Chemistry in Israel, Bulletin of the Israel Chemical Society. August 2005.

External links