INF2
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Inverted formin-2 is a protein that in humans is encoded by the INF2 gene.[1][2] It belongs to the protein family called the formins. It has two splice isoforms, CAAX which localizes to the endoplasmic reticulum and non-CAAX which localizes to focal adhesions and the cytoplasm with enrichment at the Golgi.[3][4][5] INF2 plays a role in mitochondrial fission and dorsal stress fiber formation.[5][6] INF2 accelerates actin nucleation and elongation by interacting with barbed ends (fast-growing ends) of actin filaments, but also accelerates depolymerization of actin through encircling and severing filaments.[7]
Clinical significance
It can be associated with Focal segmental glomerulosclerosis[8] and Charcot-Marie Tooth Disease.[9]
References
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Further reading
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