KLHL18

Kelch-like family member 18
Identifiers
Symbols	KLHL18 ; FLJ13703; FLJ61265; KIAA0795
External IDs	MGI: 2143315 HomoloGene: 14805 GeneCards: KLHL18 Gene
Gene ontology Molecular function • protein binding Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE KLHL18 212882 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23276	270201
Ensembl	ENSG00000114648	ENSMUSG00000054792
UniProt	O94889	E9Q4F2
RefSeq (mRNA)	NM_025010	NM_177771
RefSeq (protein)	NP_079286	NP_808439
Location (UCSC)	Chr 3: 47.28 – 47.35 Mb	Chr 9: 110.43 – 110.48 Mb
PubMed search	[1]	[2]

Kelch-like protein 18 is a protein that in humans is encoded by the KLHL18 gene.

Model organisms

Model organisms have been used in the study of KLHL18 function. A conditional knockout mouse line called Klhl18^{tm1a(KOMP)Wtsi} was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping

Klhl18 knockout mouse phenotype

Characteristic	Phenotype
All data available at.
Insulin	Normal
Homozygous viability at P14	Normal
Homozygous Fertility	Normal
Body weight	Normal
Neurological assessment	Normal
Grip strength	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Abnormal
DEXA	Normal
Radiography	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology 16 Weeks	Normal
Peripheral blood leukocytes 16 Weeks	Normal
Salmonella infection	Normal