Leukocyte immunoglobulin-like receptors
The leukocyte immunoglobulin-like receptors (LILR) are a family of receptors possessing extracellular immunoglobulin domains.[1] They are also known as CD85, ILTs and LIR, and can exert immunomodulatory effects on a wide range of immune cells.[2] The human genes encoding these receptors are found in a gene cluster at chromosomal region 19q13.4.
They include
- LILRA1
- LILRA2
- LILRA3
- LILRA4
- LILRA5
- LILRA6
- LILRB1
- LILRB2
- LILRB3
- LILRB4
- LILRB5
- LILRB6 or LILRA6
- LILRB7 or LILRA5
A subset of LILR recognise MHC class I (also known as HLA class I in humans). Of these, the inhibitory receptors LILRB1 and LILRB2 show a broad specificity for classical and non-classical MHC alleles with preferential binding to b2m-associated complexes. In contrast, the activating receptors LILRA1 and LILRA3 prefer b2m-independent free heavy chains of MHC class I, and in particular HLA-C alleles.[3]
See also
References
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Damian Brown, Rachel L Allen, & John Trowsdale. The LILR family: modulators of innate and adaptive immune pathways in health and disease. Tissue Antigens (2004) 64:215 http://onlinelibrary.wiley.com/doi/10.1111/j.0001-2815.2004.00290.x/pdf
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
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