Maltosides
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File:Decyl-beta-D-maltoside.svg
Chemical structure of n-decyl-β-D-maltopyranoside (DM)
Maltosides are a class of detergents composed of a hydrophilic maltose and a hydrophobic alkyl chain. Variation in the alkyl chain confers a range of detergent properties including CMC and solubility. Maltosides are most often used for the solubilization and purification of membrane proteins.
History
In 1980 Ferguson-Miller et al. at Michigan State developed n-dodecyl-β-D-maltopyranoside (DDM) as part of a successful effort to purify an active, stable, monodisperse form of cytochrome c oxidase.[1] Maltosides have been used extensively to stabilize membrane proteins for biophysical and structural studies.
Table of detergent properties
| Maltoside | abbr. | CMC (mM) | MW (g/mol) | Micelle (kDa) |
|---|---|---|---|---|
| n-Decyl-β-D-maltopyranoside | DM | 1.8 [2] (H20) | 482.6 | ~33 (69 molecules) [3] |
| n-Dodecyl-β-D-maltopyranoside | DDM | 0.17[4] | 510.6 | 78-149 |
| 6-Cyclohexyl-1-hexyl-β-D-maltopyranoside | Cymal-6 | 0.56 | 508.5 | 46.3 |
References
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- ↑ https://www.anatrace.com/Products/Detergents/MALTOSIDES/D322LA.aspx
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
