Metafemale

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A metafemale (or superfemale) is a low viability Drosophila fruit fly with a female phenotype in which the ratio of X chromosomes to sets of autosomes (A) exceeds 1.0.[1] For example: a fly with one X chromosome and two sets of autosomes is a normal male, a fly with two X chromosomes and two sets of autosomes is a normal female, and a fly with three X chromosomes and two sets of autosomes (or four X chromosomes and three sets of autosomes) is a metafemale.

American geneticist Calvin Bridges, who discovered the genic balance sex-determination system in Drosophila in 1921, used the terms "superfemale" and "supermale".[2] German-American geneticist Curt Stern proposed the alternate terms "metafemale" and "metamale" in 1959.[3]

References

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    genic balance: a mechanism of sex determination, originally discovered in Drosophila, that depends on the ratio of X chromosomes to sets of autosomes (A). Males develop when the X/A ratio is 0.5 or less, females develop when the X/A ratio is 1.0 or greater, an intersex develops when the ratio is between 0.5 and 1.0. See Appendix C, 1925, Bridges; metafemales, metamales, sex determination.
    metafemale: in Drosophila, a female phenotype of relatively low viability in which the ratio of X chromosomes to sets of autosomes exceeds 1.0, previously called a superfemale. See intersex, metamale.
    metamale: in Drosophila, a poorly viabile male characterized by cells containing one X and three sets of autosomes, previously called a supermale. See intersex, metafemale.
    superfemale: metafemale (q.v.).
    supermale: metamale (q.v.).
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