miR-191
| miR-191 | |
|---|---|
| 220px | |
| Conserved secondary structure of miR-191 microRNA precursor | |
| Identifiers | |
| Symbol | miR-191 |
| Alt. Symbols | MIR191 |
| Rfam | RF00764 |
| miRBase | MI0000465 |
| miRBase family | MIPF0000194 |
| Entrez | 406966 |
| HUGO | 31561 |
| RefSeq | NR_029690 |
| Other data | |
| RNA type | miRNA |
| Domain(s) | Mammalia |
| GO | 0035195 |
| SO | 0001244 |
| Locus | Chr. 3 p21.31 |
miR-191 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[1] This sequence then associates with RISC which effects RNA interference.[2]
miR-191 has been found to be dysregulated in a large number of different types of human tumour, including those of colorectal,[3] breast and prostate cancers.[4] Despite these cancer links, target genes of the mature miRNA have not been characterised, and it is not known which factors lead to its dysregulation in certain tumour cells.[5]
The expression profile of miR-191 could be implemented in prognosis of acute myeloid leukaemia, with higher than average levels of miR-191 suggesting a lower survival probability.[6]
References
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