Michael Stratton

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This article is about the cancer researcher. For the American football player, see Mike Stratton.
Michael Stratton
Born Michael Rudolf Stratton
(1957-06-22) 22 June 1957 (age 67)[1]
Institutions Wellcome Trust Sanger Institute
Institute of Cancer Research
Guy's Hospital
University of Oxford[1]
Alma mater University of Oxford
Thesis Role of genetic alterations in the genesis of human soft tissue tumours and medulloblastoma (1990)
Doctoral students Nazneen Rahman[2][3][4][5]
Known for Cancer Genome Project
Notable awards <templatestyles src="Plainlist/styles.css"/>
Spouse Judith Breuer (m. 1981)[1]
Website
www.sanger.ac.uk/research/faculty/mstratton

Sir Michael Rudolf Stratton, FRS, FMedSci, FRCPath (born 22 June 1957) is a British clinical scientist and the third director of the Wellcome Trust Sanger Institute. He currently heads the Cancer Genome Project and is a leader of the International Cancer Genome Consortium.[8][9][10][11][12][13][14][15][16][17]

Education

Stratton was educated at the independent Haberdashers' Aske's Boys' School and obtained a medical degree from Brasenose College, the University of Oxford, and Guy's Hospital before training as a histopathologist at the Hammersmith and Maudsley Hospitals in London. He obtained a PhD while working on Medulloblastomas[7] in the molecular biology of cancer at the Institute of Cancer Research.

Career

Stratton has held clinical posts at Guy’s Hospital, Westminster Hospital, Hammersmith Hospital and the Royal Marsden Hospital.[1] He took up a Faculty appointment and now holds a Professorship at the Institute of Cancer Research. He joined the Sanger Institute in 2000 and was promoted to deputy director in 2007. In May 2010, he was appointed director, succeeding Allan Bradley.[18]

Research

Michael Stratton's research interests[19] are in the area of genetics of cancer. In 1994 he assembled a research group that localized BRCA2,[20][21][22][23][24] a major breast cancer susceptibility gene that repairs chromosomal damage, to chromosome 13.[25] The following year his team identified the gene and, in doing so generated a megabase segment of high-quality human genome sequence.[26][27] His subsequent work has involved the identification of more moderate cancer susceptibility genes such as CHEK2,[28] ATM[29] and PALB2[30] each of which play a role in some breast cancers. He has additionally identified genes implicated in the development of skin, testis, colorectal and thyroid cancers, Wilms tumour and Peutz–Jeghers syndrome.[31]

At the announcement of the completion of the Human Genome Project in 2000, Stratton discussed using genome sequences to revolutionize cancer treatment.[27] He and Andy Futreal had already initiated the Cancer Genome Project at the Sanger Centre, as it was then known, to utilize genome-wide analysis to find somatic mutations in human cancers.[32] According to fellow cancer researcher Chris Marshall, doing so prior to the completion of the human genome sequence was an "audacious idea." [33] The aims of the project are to identify new cancer genes, to understand how cancers develop and to study how the structure of genomes influence cancer. In 2002 and 2004, Stratton's team discovered mutations in the BRAF[34] and ERBB2[35] genes in approximately 60 per cent of malignant melanomas and 4 per cent of non-small-cell lung cancers respectively.[31]

In 2009, Stratton and colleagues reported the first complete cancer genomes, from a lung tumour and a melanoma.[27][36] They also analyzed the genomes from 24 different breast tumours and found a diversity of DNA abnormalities, indicating that cancers can be divided in more subcategories than previously thought.[36][37] Stratton's team maintain the Catalogue of Somatic Mutations in Cancer (COSMIC) database, a set of online resources available to the scientific community.[38] He is also one of the lead researchers in the International Cancer Genome Project, a £600 million, multi-national project to sequence 25 000 cancer genomes, from 50 different types of cancer.[31] Stratton's research has been funded by the Wellcome Trust and the Medical Research Council (MRC).[39]

Awards and honours

Stratton was elected a Fellow of the Academy of Medical Sciences in 1999, elected a Fellow of the Royal Society in 2008, elected a member of EMBO in 2009[6] and was awarded the Lila Gruber Cancer Research Award in 2010. He was knighted in the 2013 Birthday Honours for services to medical science.[40][41] His nomination for the Royal Society reads: <templatestyles src="Template:Blockquote/styles.css" />

Michael Stratton is distinguished for his contributions to the genetics of human cancer. Using genetic linkage studies and positional cloning, he mapped and isolated the breast cancer susceptibility gene BRCA2 and subsequently other cancer predisposition genes: CYLD and STK11. To provide a new approach to find cancer genes he promoted the notion of large scale systematic seraches of the human genome for somatic mutations in cancer and initiated the Cancer Genome Project leading to the discovery of BRAF as a melanoma gene. His work has important implications for the understanding of the genetic mechanisms underlying cancer, diagnosis and therapy.[42]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Lua error in package.lua at line 80: module 'strict' not found. (subscription required)
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  5. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  6. ↑ 6.0 6.1 Lua error in package.lua at line 80: module 'strict' not found.
  7. ↑ 7.0 7.1 Lua error in package.lua at line 80: module 'strict' not found.(subscription required)
  8. ↑ Michael Stratton's publications indexed by the Scopus bibliographic database, a service provided by Elsevier.
  9. ↑ Michael Stratton's publications in Google Scholar
  10. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  11. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  12. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  13. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  14. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  15. ↑ Patterns of mutation in human cancer genomes — video of a seminar given by Stratton at the Royal Society.
  16. ↑ Every human 'could get their own genome sequence' — Interview with Stratton on BBC's the Today Programme
  17. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  18. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  19. ↑ List of publications from Microsoft Academic Search
  20. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  21. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  22. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  23. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  24. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  25. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  26. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  27. ↑ 27.0 27.1 27.2 Lua error in package.lua at line 80: module 'strict' not found.
  28. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  29. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  30. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  31. ↑ 31.0 31.1 31.2 Lua error in package.lua at line 80: module 'strict' not found.
  32. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  33. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  34. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  35. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  36. ↑ 36.0 36.1 Lua error in package.lua at line 80: module 'strict' not found.
  37. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  38. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  39. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  40. ↑ The London Gazette: (Supplement) no. 60534. p. 2. 15 June 2013.
  41. ↑ Michael Stratton, cancer gene scientist, knighted, BBC News, 14 June, 3013
  42. ↑ Lua error in package.lua at line 80: module 'strict' not found.


Non-profit organization positions
Preceded by Director of the Wellcome Trust Sanger Institute
2010–present		 Incumbent
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