NCS-382

NCS-382
Names
	IUPAC name (2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene ethanoic acid
Identifiers
CAS Number	131733-92-1
ChemSpider	4730868
Jmol 3D model	Interactive image
MeSH	NCS-382
PubChem	5875451
	InChI InChI=1S/C13H14O3/c14-12(15)8-10-6-3-5-9-4-1-2-7-11(9)13(10)16/h1-2,4,7-8,13,16H,3,5-6H2,(H,14,15)/b10-8+ Key: UADPGHINQMWEAG-CSKARUKUSA-N ; InChI=1/C13H14O3/c14-12(15)8-10-6-3-5-9-4-1-2-7-11(9)13(10)16/h1-2,4,7-8,13,16H,3,5-6H2,(H,14,15)/b10-8+ Key: UADPGHINQMWEAG-CSKARUKUBJ ;
	SMILES c1ccc2c(c1)CCC/C(=C\C(=O)O)/C2O ;
Properties
Chemical formula	C13H14O3
Molar mass	218.248
Vapor pressure	{{{value}}}
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

NCS-382 is a moderately selective antagonist for the GHB receptor.^[1]^[2] It blocks the effects of GHB in animals and has both anti-sedative and anticonvulsant effects.^[3]^[4]^[5] It has been proposed as a treatment for GHB overdose in humans as well as the genetic metabolic disorder succinic semialdehyde dehydrogenase deficiency (SSADHD), but has never been developed for clinical use.^[6]

References

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