NLRP4

NLR family, pyrin domain containing 4
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4EWI
Identifiers
Symbols	NLRP4 ; CLR19.5; CT58; NALP4; PAN2; PYPAF4; RNH2
External IDs	OMIM: 609645 MGI: 3056600 HomoloGene: 75315 GeneCards: NLRP4 Gene
Gene ontology Molecular function • ATP binding Cellular component • cytosol • extracellular exosome Biological process • inflammatory response • regulation of type I interferon production • positive regulation of type I interferon production • innate immune response Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	147945	83564
Ensembl	ENSG00000160505	ENSMUSG00000034690
UniProt	Q96MN2	Q3TKR3
RefSeq (mRNA)	NM_134444	NM_031389
RefSeq (protein)	NP_604393	NP_113566
Location (UCSC)	Chr 19: 55.84 – 55.88 Mb	Chr 7: 6.05 – 6.11 Mb
PubMed search	[1]	[2]

NACHT, LRR and PYD domains-containing protein 4 is a protein that in humans is encoded by the NLRP4 gene.

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003).[supplied by OMIM]