NNC 38-1049

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NNC 38-1049
NNC 38-1049.svg
Names
IUPAC name
1-(4-chlorophenyl)-4-(4-cyclopentylpiperazine-1-yl)-4-oxobutan-1-one
Identifiers
757183-18-9 YesY
ChEMBL ChEMBL97170 YesY
ChemSpider 7974195 YesY
Jmol 3D model Interactive image
PubChem 9798429
  • InChI=1S/C19H25ClN2O2/c20-16-7-5-15(6-8-16)18(23)9-10-19(24)22-13-11-21(12-14-22)17-3-1-2-4-17/h5-8,17H,1-4,9-14H2 YesY
    Key: VPARRMQGLNFBBR-UHFFFAOYSA-N YesY
  • InChI=1/C19H25ClN2O2/c20-16-7-5-15(6-8-16)18(23)9-10-19(24)22-13-11-21(12-14-22)17-3-1-2-4-17/h5-8,17H,1-4,9-14H2
    Key: VPARRMQGLNFBBR-UHFFFAOYAT
  • Clc1ccc(cc1)C(=O)CCC(=O)N3CCN(C2CCCC2)CC3
Properties
C19H25ClN2O2
Molar mass 348.866 g/mol
Vapor pressure {{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
YesY verify (what is YesYN ?)
Infobox references

NNC 38-1049 is a histamine antagonist selective for the H3 subtype. It has anorectic effects in animal studies and is being researched as a potential treatment for obesity.[1][2]

References

  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Malmlöf K, Golozoubova V, Peschke B, Wulff BS, Refsgaard HH, Johansen PB, Cremers T, Rimvall K. Increase of neuronal histamine in obese rats is associated with decreases in body weight and plasma triglycerides. Obesity (Silver Spring). 2006 Dec;14(12):2154-62. PMID 17189541

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