OTUB2

OTU deubiquitinase, ubiquitin aldehyde binding 2
250px PDB rendering based on 1tff.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1TFF, 4FJV
Identifiers
Symbols	OTUB2 ; C14orf137; OTB2; OTU2
External IDs	OMIM: 608338 MGI: 1915399 HomoloGene: 57056 GeneCards: OTUB2 Gene
EC number	3.4.19.12
Gene ontology Molecular function • ubiquitin-specific protease activity • protein binding • NEDD8-specific protease activity • ubiquitin binding Cellular component • nucleus Biological process • protein deubiquitination • protein K11-linked deubiquitination • protein K63-linked deubiquitination • protein K48-linked deubiquitination Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE OTUB2 219369 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	78990	68149
Ensembl	ENSG00000089723	ENSMUSG00000021203
UniProt	Q96DC9	Q9CQX0
RefSeq (mRNA)	NM_023112	NM_001177841
RefSeq (protein)	NP_075601	NP_001171312
Location (UCSC)	Chr 14: 94.03 – 94.05 Mb	Chr 12: 103.39 – 103.41 Mb
PubMed search	[1]	[2]

Ubiquitin thioesterase OTUB2 is an enzyme that in humans is encoded by the OTUB2 gene.

Otubains are deubiquitinating cysteine proteases (DUBs; see MIM 602519) that belong to the ovarian tumor (OTU) protein superfamily. Like other DUBs, otubains cleave proteins precisely at the ubiquitin (UB; see MIM 191339)-protein bond.