Poly(A)-specific ribonuclease

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This article is about an enzyme. For the non-profit organization, see Professional Associations Research Network.

Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Poly(A)-specific ribonuclease (PARN), also known as polyadenylate-specific ribonuclease or deadenylating nuclease (DAN), is an enzyme that in humans is encoded by the PARN gene.[1][2]

Function

Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. The amino acid sequence of poly(A)-specific ribonuclease shows homology to the RNase D family of 3'-exonucleases. The protein appears to be localized in both the nucleus and the cytoplasm. It is not stably associated with polysomes or ribosomal subunits.[2]

References

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  2. ↑ 2.0 2.1 Lua error in package.lua at line 80: module 'strict' not found.

Further reading

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