PDE2A

Phosphodiesterase 2A, cGMP-stimulated
250px PDB rendering based on 1mc0.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1Z1L, 3IBJ, 3ITM, 3ITU, 4C1I, 4D08, 4D09, 4HTX, 4HTZ, 4JIB
Identifiers
Symbols	PDE2A ; CGS-PDE; PDE2A1; PED2A4; cGSPDE
External IDs	OMIM: 602658 MGI: 2446107 HomoloGene: 1952 ChEMBL: 2652 GeneCards: PDE2A Gene
EC number	3.1.4.17
Gene ontology Molecular function • cyclic-nucleotide phosphodiesterase activity • cGMP-stimulated cyclic-nucleotide phosphodiesterase activity • calcium channel activity • protein binding • drug binding • cAMP binding • cGMP binding • TPR domain binding • protein homodimerization activity • metal ion binding Cellular component • nucleus • cytoplasm • mitochondrial matrix • endoplasmic reticulum • Golgi apparatus • cytosol • plasma membrane • presynaptic membrane • membrane raft • perinuclear region of cytoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • cAMP catabolic process • protein targeting to mitochondrion • blood coagulation • metabolic process • cAMP-mediated signaling • cGMP-mediated signaling • monocyte differentiation • negative regulation of cAMP biosynthetic process • negative regulation of protein import into nucleus, translocation • cellular response to drug • cellular response to macrophage colony-stimulating factor stimulus • negative regulation of vascular permeability • positive regulation of vascular permeability • cGMP catabolic process • positive regulation of inflammatory response • establishment of endothelial barrier • calcium ion transmembrane transport • cellular response to mechanical stimulus • cellular response to cGMP • cellular response to transforming growth factor beta stimulus • cellular response to granulocyte macrophage colony-stimulating factor stimulus Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE PDE2A 204134 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5138	207728
Ensembl	ENSG00000186642	ENSMUSG00000030653
UniProt	O00408	Q922S4
RefSeq (mRNA)	NM_001143839	NM_001008548
RefSeq (protein)	NP_001137311	NP_001008548
Location (UCSC)	Chr 11: 72.58 – 72.67 Mb	Chr 7: 101.42 – 101.51 Mb
PubMed search	[1]	[2]

cGMP-dependent 3',5'-cyclic phosphodiesterase is an enzyme that in humans is encoded by the PDE2A gene.