PEST sequence

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A PEST sequence is a peptide sequence that is rich in proline (P), glutamic acid (E), serine (S), and threonine (T). This sequence is associated with proteins that have a short intracellular half-life; hence, it is hypothesized that the PEST sequence acts as a signal peptide for protein degradation.[1]

The degradation may be mediated possibly via the proteasome[2][3] or calpain.[4]

References

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