PIAS1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). E3 SUMO-protein ligase PIAS1 is an enzyme that in humans is encoded by the PIAS1 gene.[1][2][3]
Function
This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.[3]
Interactions
PIAS1 has been shown to interact with:
- DNMT3A,[4]
- P53,[5][6]
- STAT1,[7]
- Small ubiquitin-related modifier 1,[5][8]
- Sp3 transcription factor,[9] and
- UBE2I.[5][8][9]
References
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Further reading
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