PIGH

Phosphatidylinositol glycan anchor biosynthesis, class H
Identifiers
Symbols	PIGH ; GPI-H
External IDs	OMIM: 600154 MGI: 99463 HomoloGene: 3361 GeneCards: PIGH Gene
EC number	2.4.1.198
Gene ontology Molecular function • catalytic activity • phosphatidylinositol N-acetylglucosaminyltransferase activity Cellular component • glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex • endoplasmic reticulum • endoplasmic reticulum membrane Biological process • cellular protein modification process • C-terminal protein lipidation • GPI anchor biosynthetic process • preassembly of GPI anchor in ER membrane • post-translational protein modification • cellular protein metabolic process Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE PIGH 209625 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5283	110417
Ensembl	ENSG00000100564	ENSMUSG00000021120
UniProt	Q14442	Q5M9N4
RefSeq (mRNA)	NM_004569	NM_029988
RefSeq (protein)	NP_004560	NP_084264
Location (UCSC)	Chr 14: 67.58 – 67.6 Mb	Chr 12: 79.08 – 79.09 Mb
PubMed search	[1]	[2]

Phosphatidylinositol N-acetylglucosaminyltransferase subunit H is an enzyme that in humans is encoded by the PIGH gene. The PIGH gene is located on the reverse strand of chromosome 14 in humans, and is neighbored by TMEM229B.

This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. The protein encoded by this gene is a subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum.

Interactions

PIGH has been shown to interact with PIGQ.