PRMT3

Protein arginine methyltransferase 3
250px PDB rendering based on 1f3l.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2FYT, 3SMQ, 4HSG, 4QQN, 4RYL
Identifiers
Symbols	PRMT3 ; HRMT1L3
External IDs	OMIM: 603190 MGI: 1919224 HomoloGene: 24255 ChEMBL: 5891 GeneCards: PRMT3 Gene
Gene ontology Molecular function • protein binding • methyltransferase activity • histone-arginine N-methyltransferase activity • protein-arginine N-methyltransferase activity • protein-arginine omega-N asymmetric methyltransferase activity • metal ion binding Cellular component • cytoplasm • cytosol • ribosome Biological process • regulation of transcription, DNA-templated • peptidyl-arginine methylation, to asymmetrical-dimethyl arginine • negative regulation of protein ubiquitination • histone arginine methylation Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE PRMT3 213320 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10196	71974
Ensembl	ENSG00000185238	ENSMUSG00000030505
UniProt	O60678	Q922H1
RefSeq (mRNA)	NM_001145166	NM_133740
RefSeq (protein)	NP_001138638	NP_598501
Location (UCSC)	Chr 11: 20.39 – 20.51 Mb	Chr 7: 49.78 – 49.86 Mb
PubMed search	[1]	[2]

Protein arginine N-methyltransferase 3 is an enzyme that in humans is encoded by the PRMT3 gene.

Model organisms

Prmt3 knockout mouse phenotype

Characteristic	Phenotype
Homozygote viability	Abnormal
Recessive lethal study	Normal
Fertility	Normal
General Observations	Abnormal
Body weight	Abnormal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Abnormal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Abnormal
Radiography	Normal
Body temperature	Normal
Eye morphology	Abnormal
Clinical chemistry	Normal
Haematology	Normal
Peripheral blood lymphocytes	Abnormal
Micronucleus test	Normal
Heart weight	Normal
Skin Histopathology	Normal
Brain histopathology	Normal
Eye Histopathology	Normal
Salmonella infection	Normal
Citrobacter infection	Normal
All tests and analysis from

Model organisms have been used in the study of PRMT3 function. A conditional knockout mouse line, called Prmt3^{tm1a(EUCOMM)Wtsi} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty seven tests were carried out on mutant mice and seven significant abnormalities were observed. Fewer than predicted homozygous mutant mice survived until weaning due to hydrocephaly. The remaining tests were carried out on both heterozygous and homozygous mutant adult mice. Male heterzygous mice had a decreased respiratory quotient. Homozygous females had decreased body weight, length and bone mineral density. Homozygous males had abnormal peripheral blood lymphocyte counts and homozygotes of both sex had eye abnormalities.

Interactions

PRMT3 has been shown to interact with RPS2.

External links

• PRMT3 human gene location in the UCSC Genome Browser.
• PRMT3 human gene details in the UCSC Genome Browser.