Paeonol

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Paeonol
Chemical structure of paeonol
Names
IUPAC name
1-(2-hydroxy-4-methoxyphenyl)ethanone
Other names
2'-Hydroxy-4'-methoxyacetophenone; 1-(2-hydroxy-4-methoxyphenyl)ethan-1-one
Identifiers
552-41-0[1]
ChemSpider 10621
Jmol 3D model Interactive image
PubChem 11092
  • InChI=1S/C9H10O3/c1-6(10)8-4-3-7(12-2)5-9(8)11/h3-5,11H,1-2H3
    Key: UILPJVPSNHJFIK-UHFFFAOYSA-N
  • InChI=1/C9H10O3/c1-6(10)8-4-3-7(12-2)5-9(8)11/h3-5,11H,1-2H3
    Key: UILPJVPSNHJFIK-UHFFFAOYAG
  • CC(=O)C1=C(C=C(C=C1)OC)O
Properties
C9H10O3
Molar mass 166.18 g/mol
Vapor pressure {{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Paeonol is a phenolic compound found in peony such as Paeonia suffruticosa (moutan cortex),[2][3] in Arisaema erubescens,[4] and in Dioscorea japonica.[5] It is a component found in many Traditional Chinese medicine remedies.[6]

Biological effects

Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer's disease.[7] Paeonol also reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats.[8]

It shows antimutagenic activities.[2][5] It also has anti-inflammatory and analgesic effects in carrageenan-evoked thermal hyperalgesia.[9] Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-α.[10]

It has demonstrated significant MAOI activity. MAO-A and MAO-B inhibiting effects with IC50 values of 54.6 μM and 42.5 μM respectively.[11]

References

  1. ↑ http://www.chemblink.com/products/552-41-0.htm
  2. ↑ 2.0 2.1 Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  5. ↑ 5.0 5.1 Lua error in package.lua at line 80: module 'strict' not found.
  6. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  7. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  8. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  9. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  10. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  11. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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