Protein arginine methyltransferase 5

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Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Protein arginine N-methyltransferase 5 is an enzyme that in humans is encoded by the PRMT5 gene.[1][2]

Model organisms

Model organisms have been used in the study of PRMT5 function. A conditional knockout mouse line, called Prmt5tm2a(EUCOMM)Wtsi[8][9] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[10][11][12]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[6][13] Twenty five tests were carried out on mutant mice and two significant abnormalities were observed.[6] No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice but no further abnormalities were observed.[6]

Interactions

Protein arginine methyltransferase 5 has been shown to interact with:

References

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  7. Mouse Resources Portal, Wellcome Trust Sanger Institute.
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Further reading

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