Pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)

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Pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)
Identifiers
EC number 4.3.3.6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Pyridoxal 5'-phosphate synthase (glutamine hydrolyzing) (EC 4.3.3.6, PdxST) is an enzyme with systematic name D-ribose 5-phosphate,D-glyceraldehyde 3-phosphate pyridoxal 5'-phosphate-lyase.[1][2][3][4][5][6][7][8] This enzyme catalyses the following chemical reaction

D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine \rightleftharpoons pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate (overall reaction)
(1a) L-glutamine + H2O \rightleftharpoons L-glutamate + NH3
(1b) D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 \rightleftharpoons pyridoxal 5'-phosphate + 4 H2O + phosphate

The enzyme can also use ribulose 5-phosphate and dihydroxyacetone phosphate.

References

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External links