RAB27A

RAB27A, member RAS oncogene family
Identifiers
Symbols	RAB27A ; GS2; HsT18676; RAB27; RAM
External IDs	OMIM: 603868 MGI: 1861441 HomoloGene: 3069 GeneCards: RAB27A Gene
Gene ontology Molecular function • GTPase activity • protein binding • GTP binding • GDP binding • protein domain specific binding • myosin V binding Cellular component • photoreceptor outer segment • lysosome • late endosome • Golgi apparatus • apical plasma membrane • secretory granule • dendrite • secretory granule membrane • multivesicular body membrane • Weibel-Palade body • melanosome • extracellular exosome • exocytic vesicle Biological process • protein targeting • intracellular protein transport • exocytosis • vesicle docking involved in exocytosis • blood coagulation • protein secretion • positive regulation of gene expression • antigen processing and presentation • melanocyte differentiation • melanosome localization • melanosome transport • Rab protein signal transduction • multivesicular body organization • cytotoxic T cell degranulation • natural killer cell degranulation • cellular protein metabolic process • positive regulation of exocytosis • synaptic vesicle transport • positive regulation of phagocytosis • multivesicular body sorting pathway • complement-dependent cytotoxicity • positive regulation of regulated secretory pathway • positive regulation of reactive oxygen species biosynthetic process • positive regulation of constitutive secretory pathway • exosomal secretion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5873	11891
Ensembl	ENSG00000069974	ENSMUSG00000032202
UniProt	P51159	Q9ERI2
RefSeq (mRNA)	NM_004580	NM_001301230
RefSeq (protein)	NP_004571	NP_001288159
Location (UCSC)	Chr 15: 55.2 – 55.32 Mb	Chr 9: 73.04 – 73.1 Mb
PubMed search	[1]	[2]

Ras-related protein Rab-27A is a protein that in humans is encoded by the RAB27A gene.

Function

The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.

The RAB27A gene is regulated by the Microphthalmia-associated transcription factor.

Interactions

RAB27A has been shown to interact with:

• EXPH5,
• MYO5A,
• RPH3AL
• SYTL1, and
• SYTL2.

See also

• Rab27