RIPK1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Receptor-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the RIPK1 gene.[1][2][3] RIPK1 is known to have function in a variety of cellular pathways including the NF-κB pathway and programmed necrotic cell death (necroptosis).
Function
Although, RIPK1 has been primarily studied in the context of TNFR signaling, RIPk1 is also activated in response to diverse stimuli.[4]
The kinase domain, while important for necroptotic (programmed necrotic) functions, it appears dispensable for pro-survival roles. Kinase activity of RIPK1 is also required for RIPK1-dependent apoptosis in conditions of IAP1/2 depletion, TAK1inhibition/depletion, RIPK3 depletion or MLKL depletion.[5][6] Also, proteolytic processing of RIPk1, through both caspase-dependent and -independent mechanisms, triggers lethality that is dependent on the generation of one or more specific C-terminal cleavage product(s) of RIPk1 upon stress.
Interactions
RIPK1 has been shown to interact with:
- BIRC2,[7]
- BIRC3,[7]
- CA11,[8]
- CASP8,[7][9][10]
- CFLAR,[9][11]
- CRADD,[12][13]
- RIPK3,[14][15]
- RNF11,[16]
- RNF216,[17]
- SQSTM1,[18]
- TNFRSF1A,[2][12][19][20][21][22]
- TRADD,[2]
- TRAF2,[2][23][24][25] and
- UBC.[7][8][21][22][26]
References
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Further reading
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