Rosenthal fiber
H&E staining showing these elongated eosinophilic structures in a case of pilocytic astrocytoma. Magnification 400x
A Rosenthal fiber is a thick, elongated, worm-like or "corkscrew" eosinophilic (pink) bundle that is found on H&E staining of the brain in the presence of long-standing gliosis, occasional tumors, and some metabolic disorders.
Associated conditions
Its presence is associated with either pilocytic astrocytoma[1] (more common) or Alexander's disease (a rare leukodystrophy). They are also seen in the context of fucosidosis.
Pilocytic astrocytoma is the most common primitive tumor in pediatric patients.
Composition
The fibers are found in astrocytic processes and are thought to be clumped intermediate filament proteins.
Their components include glial fibrillary acidic protein.[2]
References
External links
- Neuropathology Mini-Course. Chapter 9 - Tumors of the Nervous System
- Doctor's Doctor - Brain and Spinal Cord
- Isolation of a major protein component of Rosenthal fibers
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