SMYD4

SET and MYND domain containing 4
Identifiers
Symbols	SMYD4 ; ZMYND21
External IDs	MGI: 2442796 HomoloGene: 35098 GeneCards: SMYD4 Gene
Gene ontology Molecular function • methyltransferase activity • metal ion binding Cellular component • nucleus Biological process • methylation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	114826	319822
Ensembl	ENSG00000186532	ENSMUSG00000018809
UniProt	Q8IYR2	Q8BTK5
RefSeq (mRNA)	NM_052928	NM_001102611
RefSeq (protein)	NP_443160	NP_001096081
Location (UCSC)	Chr 17: 1.78 – 1.83 Mb	Chr 11: 75.35 – 75.41 Mb
PubMed search	[1]	[2]

SET and MYND domain-containing protein 4 is a protein that in humans is encoded by the SMYD4 gene.

Model organisms

Smyd4 knockout mouse phenotype

Characteristic	Phenotype
Homozygote viability	Normal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Plasma immunoglobulins	Normal
Haematology	Normal
Peripheral blood lymphocytes	Normal
Micronucleus test	Normal
Heart weight	Normal
Tail epidermis wholemount	Normal
Skin Histopathology	Normal
Brain histopathology	Normal
Eye Histopathology	Normal
Salmonella infection	Normal
Citrobacter infection	Normal
All tests and analysis from

Model organisms have been used in the study of SMYD4 function. A conditional knockout mouse line, called Smyd4^{tm1a(EUCOMM)Wtsi} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty six tests were carried out on homozygous mutant adult mice, however no significant abnormalities were observed.