STUB1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). STUB1 (STIP1 homology and U-Box containing protein 1), also known as CHIP (C terminus of HSC70-Interacting Protein), is a human gene.[1][2]
Function
The CHIP protein encoded by this gene binds to and inhibits the ATPase activity of the chaperone proteins HSC70 and HSP70 and blocks the forward reaction of the HSC70-HSP70 substrate-binding cycle.[2] In addition, CHIP possesses E3 ubiquitin ligase activity and promotes ubiquitylation.[3] CHIP enhances HSP70 induction during acute stress and also mediates its turnover during the stress recovery process. Hence CHIP appears to maintain protein homeostasis by controlling chaperone levels during stress and recovery.[4]
Mutations in STUB1 cause ataxia .[5]
Interactions
STUB1 has been shown to interact with:
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References
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Further reading
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External links
- STUB1 human gene location in the UCSC Genome Browser.
- STUB1 human gene details in the UCSC Genome Browser.
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