TOPBP1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). DNA topoisomerase 2-binding protein 1 is an enzyme that in humans is encoded by the TOPBP1 gene.[1][2][3]
Function
This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.[3]
Interactions
TOPBP1 has been shown to interact with:
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Clinical relevance
This gene may be involved in the development of ovarian and breast cancer.[10]
Mutations in TOPBP1 cause Idiopathic pulmonary arterial hypertension .[11]
References
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- ↑ Forma E, Wójcik-Krowiranda K, Bieńkiewicz A, Bryś M (2013) Molecular basis of gynecological oncology - TopBP1 protein as the guardian of genome integrity. Ginekol Pol 84(5):373-376
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Further reading
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