TRPV6

Transient receptor potential cation channel, subfamily V, member 6
Identifiers
Symbols	TRPV6 ; ABP/ZF; CAT1; CATL; ECAC2; HSA277909; LP6728; ZFAB
External IDs	OMIM: 606680 MGI: 1927259 HomoloGene: 56812 IUPHAR: 512 ChEMBL: 1628465 GeneCards: TRPV6 Gene
Gene ontology Molecular function • calcium channel activity • protein binding • calmodulin binding Cellular component • plasma membrane • integral component of plasma membrane • extracellular exosome Biological process • calcium ion transport • regulation of calcium ion-dependent exocytosis • ion transmembrane transport • parathyroid hormone secretion • calcium ion homeostasis • transmembrane transport • calcium ion transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE TRPV6 206827 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55503	64177
Ensembl	ENSG00000165125	ENSMUSG00000029868
UniProt	Q9H1D0	Q91WD2
RefSeq (mRNA)	NM_014274	NM_022413
RefSeq (protein)	NP_061116	NP_071858
Location (UCSC)	Chr 7: 142.87 – 142.89 Mb	Chr 6: 41.62 – 41.64 Mb
PubMed search	[1]	[2]

TRPV6 is a membrane calcium channel which is particularly involved in the first step in calcium absorption in the intestine.

Nomenclature

When first discovered it was named CAT1, or ECaC2. The name TRPV6 was confirmed in 2005.

TRPV6 is a member of the transient receptor potential (TRP) family of membrane proteins. Unlike most TRP channels, TRPV6 is selective for Ca²⁺ ions, a property shared with its close homologue, TRPV5, which is mainly expressed in the kidney and plays a role in renal Ca²⁺ reabsorption.

Expression

TRPV6 expression has been described in the intestine in several species, including humans. The protein is located in the apical brush-border membrane of the intestinal enterocyte where it regulates calcium entry into the cell. It is most abundant in the proximal small intestine (duodenum and jejunum), along with the other calcium transport proteins, calbindin and the calcium-pumping ATPase, PMCA1. The TRPV6 calcium transporter also found in the human placenta, pancreas and prostate gland and in some species in the kidney, where the related channel TRPV5 is strongly expressed.

Regulation of expression

Vitamin D

Expression of TRPV6 is vitamin D dependent in mice and humans. Its expression was greatly reduced in animals that do not express the vitamin D receptor.

Vitamin D treatment of human colon cancer cells, Caco-2, increased expression of TRPV6 transcripts, and also stimulated the transport of calcium, probably through increased TRPV6 expression. In human duodenal explants, TRPV6 transcript expression was increased 3-fold after 6h incubation with the active form of vitamin D, 1,25-dihydroxycholecalciferol.

See also

• TRPV

External links

• TRPV Cation Channels at the US National Library of Medicine Medical Subject Headings (MeSH)
• TRPV6 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)