Template:PBB/1490

Connective tissue growth factor
Identifiers
Symbols	CTGF ; CCN2; HCS24; IGFBP8; NOV2
External IDs	OMIM: 121009 MGI: 95537 HomoloGene: 1431 GeneCards: CTGF Gene
Gene ontology Molecular function • fibronectin binding • integrin binding • protein binding • insulin-like growth factor binding • protein C-terminus binding • growth factor activity • heparin binding Cellular component • extracellular region • proteinaceous extracellular matrix • extracellular space • Golgi apparatus • cis-Golgi network • cytosol • plasma membrane • cell cortex • intracellular membrane-bounded organelle • perinuclear region of cytoplasm Biological process • cartilage condensation • ossification • angiogenesis • regulation of cell growth • tissue homeostasis • transcription initiation from RNA polymerase II promoter • cell adhesion • cell-matrix adhesion • signal transduction • integrin-mediated signaling pathway • cell-cell signaling • positive regulation of cell proliferation • fibroblast growth factor receptor signaling pathway • epidermis development • response to wounding • response to glucose • organ senescence • gene expression • positive regulation of gene expression • negative regulation of gene expression • cell migration • cell differentiation • lung development • regulation of chondrocyte differentiation • response to estradiol • positive regulation of collagen biosynthetic process • response to anoxia • intracellular signal transduction • chondrocyte proliferation • response to amino acid • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • response to peptide hormone • cellular lipid metabolic process • small molecule metabolic process • positive regulation of cell differentiation • positive regulation of JNK cascade • positive regulation of cell activation • response to mineralocorticoid • positive regulation of stress fiber assembly • cytosolic calcium ion transport • positive regulation of cardiac muscle contraction • negative regulation of cell death • extracellular matrix constituent secretion • positive regulation of G0 to G1 transition • positive regulation of ERK1 and ERK2 cascade • response to fatty acid • DNA biosynthetic process • reactive oxygen species metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1490	14219
Ensembl	ENSG00000118523	ENSMUSG00000019997
UniProt	P29279	P29268
RefSeq (mRNA)	NM_001901	NM_010217
RefSeq (protein)	NP_001892	NP_034347
Location (UCSC)	Chr 6: 131.95 – 131.95 Mb	Chr 10: 24.6 – 24.6 Mb
PubMed search	[1]	[2]