Template:PBB/1565

Cytochrome P450, family 2, subfamily D, polypeptide 6
PDB rendering based on 2f9q.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2F9Q, 3QM4, 3TBG, 3TDA, 4WNT, 4WNU, 4WNV, 4WNW
Identifiers
Symbols	CYP2D6 ; CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1
External IDs	OMIM: 124030 MGI: 1929474 HomoloGene: 133550 GeneCards: CYP2D6 Gene
EC number	1.14.14.1
Gene ontology Molecular function • monooxygenase activity • iron ion binding • drug binding • arachidonic acid epoxygenase activity • steroid hydroxylase activity • oxidoreductase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • oxygen binding • heme binding • aromatase activity Cellular component • cytoplasm • mitochondrion • endoplasmic reticulum • endoplasmic reticulum membrane Biological process • xenobiotic metabolic process • steroid metabolic process • coumarin metabolic process • alkaloid metabolic process • alkaloid catabolic process • monoterpenoid metabolic process • drug metabolic process • arachidonic acid metabolic process • isoquinoline alkaloid metabolic process • drug catabolic process • exogenous drug catabolic process • small molecule metabolic process • heterocycle metabolic process • negative regulation of binding • oxidation-reduction process • oxidative demethylation • negative regulation of cellular organofluorine metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1565	13101
Ensembl	ENSG00000100197	ENSMUSG00000094806
UniProt	P10635	P24456
RefSeq (mRNA)	NM_000106	NM_010005
RefSeq (protein)	NP_000097	NP_034135
Location (UCSC)	Chr 22: 42.13 – 42.13 Mb	Chr 15: 82.4 – 82.41 Mb
PubMed search	[1]	[2]