Template:PBB/1956

Epidermal growth factor receptor
Extracellular domain of Epidermal growth factor receptor in complex with EGF. PDB 1nql
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1DNQ, 1DNR, 1IVO, 1M14, 1M17, 1MOX, 1NQL, 1XKK, 1YY9, 1Z9I, 2EB2, 2EB3, 2EXP, 2EXQ, 2GS2, 2GS6, 2GS7, 2ITN, 2ITO, 2ITP, 2ITQ, 2ITT, 2ITU, 2ITV, 2ITW, 2ITX, 2ITY, 2ITZ, 2J5E, 2J5F, 2J6M, 2JIT, 2JIU, 2JIV, 2KS1, 2M0B, 2M20, 2RF9, 2RFD, 2RFE, 2RGP, 3B2U, 3B2V, 3BEL, 3BUO, 3C09, 3G5V, 3G5Y, 3GOP, 3GT8, 3IKA, 3LZB, 3NJP, 3OB2, 3OP0, 3P0Y, 3PFV, 3POZ, 3QWQ, 3UG1, 3UG2, 3VJN, 3VJO, 3VRP, 3VRR, 3W2O, 3W2P, 3W2Q, 3W2R, 3W2S, 3W32, 3W33, 4G5J, 4G5P, 4HJO, 4I1Z, 4I20, 4I21, 4I22, 4I23, 4I24, 4JQ7, 4JQ8, 4JR3, 4JRV, 4KRL, 4KRM, 4KRO, 4KRP, 4LI5, 4LL0, 4LQM, 4LRM, 4R5S, 4RIW, 4RIX, 4RIY, 4RJ4, 4RJ5, 4RJ6, 4RJ7, 4RJ8, 4TKS, 4WKQ, 4WRG
Identifiers
Symbols	EGFR ; ERBB; ERBB1; HER1; NISBD2; PIG61; mENA
External IDs	OMIM: 131550 MGI: 95294 HomoloGene: 74545 ChEMBL: 203 GeneCards: EGFR Gene
EC number	2.7.10.1
Gene ontology Molecular function • chromatin binding • double-stranded DNA binding • MAP kinase kinase kinase activity • protein tyrosine kinase activity • transmembrane receptor protein tyrosine kinase activity • receptor signaling protein tyrosine kinase activity • transmembrane signaling receptor activity • epidermal growth factor-activated receptor activity • protein binding • ATP binding • enzyme binding • protein phosphatase binding • nitric-oxide synthase regulator activity • ubiquitin protein ligase binding • identical protein binding • protein heterodimerization activity • actin filament binding Cellular component • Golgi membrane • extracellular space • nucleus • cytoplasm • endosome • endoplasmic reticulum membrane • plasma membrane • focal adhesion • cell surface • endosome membrane • membrane • integral component of membrane • basolateral plasma membrane • AP-2 adaptor complex • early endosome membrane • nuclear membrane • receptor complex • membrane raft • perinuclear region of cytoplasm • Shc-EGFR complex • multivesicular body, internal vesicle lumen Biological process • MAPK cascade • activation of MAPKK activity • ossification • embryonic placenta development • positive regulation of protein phosphorylation • hair follicle development • response to stress • signal transduction • cell surface receptor signaling pathway • epidermal growth factor receptor signaling pathway • activation of phospholipase C activity • axon guidance • salivary gland morphogenesis • learning or memory • cell proliferation • positive regulation of cell proliferation • fibroblast growth factor receptor signaling pathway • single organismal cell-cell adhesion • peptidyl-tyrosine phosphorylation • cerebral cortex cell migration • positive regulation of cell migration • positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle • positive regulation of catenin import into nucleus • Fc-epsilon receptor signaling pathway • negative regulation of epidermal growth factor receptor signaling pathway • negative regulation of protein catabolic process • positive regulation of phosphorylation • activation of phospholipase A2 activity by calcium-mediated signaling • negative regulation of apoptotic process • positive regulation of MAP kinase activity • innate immune response • positive regulation of nitric oxide biosynthetic process • positive regulation of DNA repair • positive regulation of DNA replication • positive regulation of transcription from RNA polymerase II promoter • protein autophosphorylation • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • positive regulation of fibroblast proliferation • digestive tract morphogenesis • positive regulation of epithelial cell proliferation • regulation of peptidyl-tyrosine phosphorylation • regulation of nitric-oxide synthase activity • protein insertion into membrane • positive regulation of protein kinase B signaling • morphogenesis of an epithelial fold • response to UV-A • positive regulation of ERK1 and ERK2 cascade • cellular response to amino acid stimulus • cellular response to epidermal growth factor stimulus • cellular response to estradiol stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1956	13649
Ensembl	ENSG00000146648	ENSMUSG00000020122
UniProt	P00533	Q01279
RefSeq (mRNA)	NM_005228	NM_007912
RefSeq (protein)	NP_005219	NP_031938
Location (UCSC)	Chr 7: 55.02 – 55.26 Mb	Chr 11: 16.75 – 16.92 Mb
PubMed search	[1]	[2]