Template:PBB/6347

Chemokine (C-C motif) ligand 2
250px PDB rendering based on 1dok.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1DOK, 1DOL, 1DOM, 1DON, 1MCA, 1ML0, 2BDN, 2NZ1, 3IFD, 4DN4, 4R8I
Identifiers
Symbols	CCL2 ; GDCF-2; HC11; HSMCR30; MCAF; MCP-1; MCP1; SCYA2; SMC-CF
External IDs	OMIM: 158105 MGI: 98259 HomoloGene: 2245 ChEMBL: 1649052 GeneCards: CCL2 Gene
Gene ontology Molecular function • protein kinase activity • receptor binding • chemokine activity • heparin binding • CCR2 chemokine receptor binding Cellular component • extracellular region • extracellular space • rough endoplasmic reticulum • endocytic vesicle • dendrite • perikaryon • axon terminus • C-fiber • synapse • perinuclear region of cytoplasm Biological process • MAPK cascade • angiogenesis • response to hypoxia • positive regulation of leukocyte mediated cytotoxicity • positive regulation of endothelial cell proliferation • leukocyte migration involved in inflammatory response • monocyte chemotaxis • positive regulation of cellular extravasation • protein phosphorylation • cellular calcium ion homeostasis • chemotaxis • inflammatory response • humoral immune response • cytoskeleton organization • cell adhesion • signal transduction • cell surface receptor signaling pathway • transforming growth factor beta receptor signaling pathway • G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • JAK-STAT cascade • aging • regulation of cell shape • response to heat • response to wounding • response to mechanical stimulus • response to bacterium • organ morphogenesis • response to gamma radiation • regulation of vascular endothelial growth factor production • positive regulation of macrophage chemotaxis • response to activity • negative regulation of angiogenesis • viral genome replication • cytokine-mediated signaling pathway • cellular homeostasis • neutrophil chemotaxis • endoplasmic reticulum unfolded protein response • organ regeneration • lipopolysaccharide-mediated signaling pathway • response to progesterone • positive regulation of tumor necrosis factor production • cellular response to insulin stimulus • positive regulation of collagen biosynthetic process • response to vitamin B3 • negative regulation of glial cell apoptotic process • helper T cell extravasation • cellular response to drug • cellular response to macrophage colony-stimulating factor stimulus • cellular response to platelet-derived growth factor stimulus • PERK-mediated unfolded protein response • response to amino acid • protein kinase B signaling • negative regulation of neuron apoptotic process • positive regulation of GTPase activity • astrocyte cell migration • cellular protein metabolic process • cellular response to fibroblast growth factor stimulus • response to ethanol • response to antibiotic • vascular endothelial growth factor receptor signaling pathway • eosinophil chemotaxis • macrophage chemotaxis • lymphocyte chemotaxis • positive regulation of synaptic transmission • positive regulation of T cell activation • positive regulation of nitric-oxide synthase biosynthetic process • maternal process involved in female pregnancy • maternal process involved in parturition • chemokine-mediated signaling pathway • positive regulation of ERK1 and ERK2 cascade • cellular response to lipopolysaccharide • cellular response to retinoic acid • cellular response to ATP • cellular response to interferon-gamma • cellular response to interleukin-1 • cellular response to interleukin-6 • cellular response to tumor necrosis factor • cellular response to high density lipoprotein particle stimulus • cellular response to organic cyclic compound • cellular response to dexamethasone stimulus • positive regulation of monocyte chemotaxis • positive regulation of immune complex clearance by monocytes and macrophages • positive regulation of calcium ion import • positive regulation of protein targeting to membrane • positive regulation of apoptotic cell clearance • negative regulation of natural killer cell chemotaxis Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE CCL2 216598 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6347	20293
Ensembl	ENSG00000108691	ENSMUSG00000035352
UniProt	P13500	Q62401
RefSeq (mRNA)	NM_002982	NM_011331
RefSeq (protein)	NP_002973	NP_035461
Location (UCSC)	Chr 17: 34.26 – 34.26 Mb	Chr 11: 82.1 – 82.1 Mb
PubMed search	[1]	[2]