Template:PBB/7454

Wiskott-Aldrich syndrome
250px PDB rendering based on 1cee.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1CEE, 1EJ5, 1T84, 2A3Z, 2K42, 2OT0
Identifiers
Symbols	WAS ; IMD2; SCNX; THC; THC1; WASP; WASPA
External IDs	OMIM: 300392 MGI: 105059 HomoloGene: 30970 GeneCards: WAS Gene
Gene ontology Molecular function • actin binding • protein binding • SH3 domain binding • protein kinase binding • GTPase regulator activity • identical protein binding • phospholipase binding Cellular component • cytosol • cell-cell junction • vesicle membrane • actin cytoskeleton • extracellular exosome Biological process • regulation of T cell antigen processing and presentation • protein complex assembly • defense response • immune response • small GTPase mediated signal transduction • blood coagulation • actin polymerization or depolymerization • epidermis development • endosomal transport • actin filament polymerization • actin filament-based movement • Fc-gamma receptor signaling pathway involved in phagocytosis • T cell activation • innate immune response • regulation of catalytic activity • T cell receptor signaling pathway • negative regulation of cell motility • positive regulation of Arp2/3 complex-mediated actin nucleation Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE WAS 38964 r at tn.png
File:PBB GE WAS 205400 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7454	22376
Ensembl	ENSG00000015285	ENSMUSG00000031165
UniProt	P42768	P70315
RefSeq (mRNA)	NM_000377	NM_009515
RefSeq (protein)	NP_000368	NP_033541
Location (UCSC)	Chr X: 48.68 – 48.69 Mb	Chr X: 8.08 – 8.09 Mb
PubMed search	[1]	[2]