Template:PBB/796

Calcitonin-related polypeptide alpha
NMR solution structure of salmon calcitonin in SDS micelles.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1LS7, 2JXZ
Identifiers
Symbols	CALCA ; CALC1; CGRP; CGRP-I; CGRP1; CT; KC
External IDs	OMIM: 114130 MGI: 2151253 HomoloGene: 88401 ChEMBL: 5293 GeneCards: CALCA Gene
Gene ontology Molecular function • receptor binding • hormone activity • protein binding • calcitonin receptor binding • protein complex binding • identical protein binding Cellular component • extracellular region • extracellular space • nucleus • cytoplasm • cytosol • neuronal cell body • terminal bouton Biological process • endothelial cell proliferation • vasculature development • neurological system process involved in regulation of systemic arterial blood pressure • vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure • regulation of heart rate • G-protein coupled receptor internalization • monocyte chemotaxis • protein phosphorylation • inflammatory response • leukocyte cell-cell adhesion • adenylate cyclase-activating G-protein coupled receptor signaling pathway • activation of adenylate cyclase activity • positive regulation of cytosolic calcium ion concentration • neuropeptide signaling pathway • cell-cell signaling • embryo implantation • aging • feeding behavior • regulation of blood pressure • response to heat • negative regulation of calcium ion transport into cytosol • negative regulation of ossification • positive regulation of cAMP biosynthetic process • receptor internalization • negative regulation of neurological system process • activation of protein kinase activity • positive regulation of interleukin-1 alpha production • positive regulation of interleukin-8 production • endothelial cell migration • positive regulation of macrophage differentiation • negative regulation of osteoclast differentiation • positive regulation of adenylate cyclase activity • negative regulation of blood pressure • positive regulation of ossification • negative regulation of bone resorption • negative regulation of transcription, DNA-templated • positive regulation of vasodilation • negative regulation of smooth muscle contraction • response to pain • detection of temperature stimulus involved in sensory perception of pain • cytosolic calcium ion homeostasis • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway • cellular response to tumor necrosis factor • cellular response to nerve growth factor stimulus Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE CALCA 210728 s at tn.png
File:PBB GE CALCA 210727 at tn.png
File:PBB GE CALCA 217495 x at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	796	12310
Ensembl	ENSG00000110680	ENSMUSG00000030669
UniProt	P01258	P70160
RefSeq (mRNA)	NM_001033952	NM_001033954
RefSeq (protein)	NP_001029124	NP_001029126
Location (UCSC)	Chr 11: 14.97 – 14.97 Mb	Chr 7: 114.63 – 114.64 Mb
PubMed search	[1]	[2]

References

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