Template:PBB/948
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CD36 molecule (thrombospondin receptor)
Predicted
topology
of CD36 in the
plasma membrane
Identifiers
Symbols
CD36
; BDPLT10; CHDS7; FAT; GP3B; GP4; GPIV; PASIV; SCARB3
External IDs
OMIM
:
173510
MGI
:
107899
HomoloGene
:
73871
ChEMBL
:
1744526
GeneCards
:
CD36 Gene
Gene ontology
Molecular function
•
low-density lipoprotein receptor activity
•
high-density lipoprotein particle binding
•
lipid binding
•
low-density lipoprotein particle binding
•
transforming growth factor beta binding
•
thrombospondin receptor activity
•
lipoteichoic acid receptor activity
•
lipoprotein particle binding
Cellular component
•
extracellular space
•
Golgi apparatus
•
plasma membrane
•
integral component of plasma membrane
•
external side of plasma membrane
•
cell surface
•
membrane
•
endocytic vesicle membrane
•
platelet alpha granule membrane
•
membrane raft
•
phagocytic vesicle
Biological process
•
negative regulation of transcription from RNA polymerase II promoter
•
positive regulation of cell-matrix adhesion
•
toll-like receptor signaling pathway
•
antigen processing and presentation of peptide antigen via MHC class I
•
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
•
platelet degranulation
•
MyD88-dependent toll-like receptor signaling pathway
•
lipid metabolic process
•
receptor-mediated endocytosis
•
phagocytosis, recognition
•
cell adhesion
•
cell surface receptor signaling pathway
•
nitric oxide mediated signal transduction
•
blood coagulation
•
positive regulation of macrophage derived foam cell differentiation
•
positive regulation of cholesterol storage
•
plasma membrane long-chain fatty acid transport
•
lipid storage
•
cGMP-mediated signaling
•
platelet activation
•
positive regulation of blood coagulation
•
cholesterol transport
•
positive regulation of interleukin-12 production
•
positive regulation of interleukin-6 production
•
positive regulation of tumor necrosis factor production
•
toll-like receptor 2 signaling pathway
•
toll-like receptor 4 signaling pathway
•
plasma lipoprotein particle clearance
•
low-density lipoprotein particle clearance
•
response to stilbenoid
•
toll-like receptor TLR1:TLR2 signaling pathway
•
toll-like receptor TLR6:TLR2 signaling pathway
•
antigen processing and presentation of exogenous peptide antigen via MHC class I
•
lipoprotein transport
•
negative regulation of transcription factor import into nucleus
•
positive regulation of I-kappaB kinase/NF-kappaB signaling
•
apoptotic cell clearance
•
positive regulation of MAPK cascade
•
negative regulation of growth of symbiont in host
•
cellular lipid metabolic process
•
small molecule metabolic process
•
long-chain fatty acid import
•
innate immune response
•
positive regulation of peptidyl-tyrosine phosphorylation
•
defense response to Gram-positive bacterium
•
low-density lipoprotein particle mediated signaling
•
positive regulation of phagocytosis, engulfment
•
positive regulation of macrophage cytokine production
•
cellular response to bacterial lipopeptide
•
cellular response to lipopolysaccharide
•
cellular response to lipoteichoic acid
•
cellular response to hydroperoxide
•
regulation of removal of superoxide radicals
•
positive regulation of blood microparticle formation
•
positive regulation of reactive oxygen species metabolic process
Sources:
Amigo
/
QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species
Human
Mouse
Entrez
948
12491
Ensembl
ENSG00000135218
ENSMUSG00000002944
UniProt
P16671
Q08857
RefSeq (mRNA)
NM_000072
NM_001159555
RefSeq (protein)
NP_000063
NP_001153027
Location (UCSC)
Chr 7:
80.37 – 80.68 Mb
Chr 5:
17.78 – 17.89 Mb
PubMed
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