Thymopentin

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Thymopentin
File:Thymopentin.png
Systematic (IUPAC) name
L-arginyl-L-lysyl-L-α-aspartyl-L-valyl-L-tyrosine
Identifiers
ATC code L03AX09 (WHO)
PubChem CID: 451417
ChemSpider 397640 YesY
UNII O3Y80ZF13F YesY
KEGG D06117 YesY
ChEMBL CHEMBL156025 YesY
NIAID ChemDB 000127
Synonyms (3S)-3-[[(2S)-6-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-[[(2S)-1-[[(2S)-1-hydroxy-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
Chemical data
Formula C30H49N9O9
Molecular mass 679.76496 g/mol
  • O=C(N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccc(O)cc1)C(C)C)CC(=O)O)CCCCN)[C@@H](N)CCC/N=C(\N)N
  • InChI=1S/C30H49N9O9/c1-16(2)24(28(46)38-22(29(47)48)14-17-8-10-18(40)11-9-17)39-27(45)21(15-23(41)42)37-26(44)20(7-3-4-12-31)36-25(43)19(32)6-5-13-35-30(33)34/h8-11,16,19-22,24,40H,3-7,12-15,31-32H2,1-2H3,(H,36,43)(H,37,44)(H,38,46)(H,39,45)(H,41,42)(H,47,48)(H4,33,34,35)/t19-,20-,21-,22-,24-/m0/s1 YesY
  • Key:PSWFFKRAVBDQEG-YGQNSOCVSA-N YesY
  (verify)

Thymopentin is an immunostimulant. As such, it has been used in several clinical studies in the early years of the AIDS pandemic (from 1983 to 1985). Thymopentin helped to improve immunological condition in several patients for a brief time under specific treatments.[1][2][3]

It interacts with T cells.[4]

It is a thymic polypeptide.[5]

References

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  4. Lua error in package.lua at line 80: module 'strict' not found. open access publication - free to read
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