VCX

Variable charge, X-linked
Identifiers
Symbols	VCX ; VCX-10r; VCX-B1; VCX1; VCX10R; VCXB1
External IDs	OMIM: 300229 HomoloGene: 88395 GeneCards: VCX Gene
Gene ontology Molecular function • chromatin binding Cellular component • nucleus • nucleolus Biological process • chromatin organization • spermatogenesis • ribosome assembly Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE VCX 207281 x at tn.png
File:PBB GE VCX 211403 x at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26609	n/a
Ensembl	ENSG00000169059	n/a
UniProt	Q9H320	n/a
RefSeq (mRNA)	NM_013452	n/a
RefSeq (protein)	NP_038480	n/a
Location (UCSC)	Chr X: 6.53 – 6.54 Mb	n/a
PubMed search	[1]	n/a

Variable charge X-linked protein 1 is a protein that in humans is encoded by the VCX gene.

This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 10 repeats of the 30-bp unit.