APPL1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). DCC-interacting protein 13-alpha is a protein that in humans is encoded by the APPL1 gene.[1][2][3]
The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.[3]
| Mouse Mutant Alleles for Appl1 | ||
|---|---|---|
| Marker Symbol for Mouse Gene. This symbol is assigned to the genomic locus by the MGI | Appl1 | |
| Mutant Mouse Embryonic Stem Cell Clones. These are the known targeted mutations for this gene in a mouse. | Appl1tm1a(KOMP)Wtsi | |
| Example structure of targeted conditional mutant allele for this gene | ||
Wtsi.jpg) |
||
| These Mutant ES Cells can be studied directly or used to generate mice with this gene knocked out. Study of these mice can shed light on the function of Appl1:
see Knockout mouse |
||
Interactions
APPL1 has been shown to interact with Deleted in Colorectal Cancer[4] and AKT2.[1]
References
Further reading
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This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it. |
